Who.Muat You Convince To.Remove Your.Name.From.A Film.As Director Fighting Cancer With Whey

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Fighting Cancer With Whey

Studies on whey show that it is a better protein supplement than previously thought. Although the health benefits of whey protein have only recently been elucidated, the use of whey protein for medicinal purposes has been prescribed since the time of Hippocrates. In fact, there are two ancient proverbs from the city of Florence in Italy that say, “If you want to live a healthy and active life, drink whey,” and, “If everything was raised on whey, doctors would go bankrupt. “

In previous issues, we’ve chronicled the extensive research showing the many potential health benefits of whey protein concentrate. Most of that research was done in the 1980s and early 1990s, and was very persuasive. Scientists have continued their research on whey proteins with even more impressive results. The following is some of the more current, interesting and useful research on whey proteins.

Fish sauce and Cancer

Additional studies were done on animals regarding cancer-causing chemicals to see what effect whey protein concentrate would have on cancer prevention or treatment. The scientists fed mice different proteins and then subjected them to the powerful carcinogen dimethylhydrazine.

As in previous research, mice fed whey protein concentrate showed fewer tumors and a reduced pooled area of ​​tumors (tumor mass index). The researchers found that whey protein offered “significant host protection” over other proteins, including soy. 1

More exciting, in vivo research on cancer and whey showed that whey protein concentrate inhibited the growth of breast cancer cells at low concentrations (Baruchel S. and Vaiu G., Anti Cancer Research, 1996) . Finally, and most importantly, a relatively recent clinical study on cancer patients showed regression of some patient tumors when feeding whey protein concentrate at 30 grams per day. 2

Whey and Glutathione

This new research using whey protein concentrate led researchers to an amazing discovery about the relationship between cancerous cells, glutathione (GSH) and whey protein concentrate. Whey protein concentrate has been found to selectively deplete cancer cells of their glutathione, thus making them more susceptible to cancer treatments such as radiation and chemotherapy.

Cancer cells and normal cells have been found to respond differently to nutrients and drugs that affect glutathione status. What is most interesting to note is the fact that the concentration of glutathione in tumor cells is higher than in the normal cells surrounding it. This difference in glutathione status between normal cells and cancer cells is believed to be an important factor in the resistance of cancer cells to chemotherapy.

As the researchers said, “Tumor cell GSH concentration may be among the determinants of cytotoxicity [poisonous to cells] by many chemotherapeutic agents and by radiation, and an increase in GSH concentration appears to be at least one of the mechanisms of acquired chemotherapy drug resistance.”

They further stated, “It is well known that the rapid synthesis of GSH in tumor cells is associated with a high rate of cellular proliferation. Depletion of tumor GSH in vivo decreases the rate of cellular proliferation and inhibits the growth of cancer.”

The problem is, it is difficult to reduce glutathione sufficiently in tumor cells without endangering healthy tissue and putting the cancer patient in a worse condition. What is needed is a compound that can selectively deplete cancer cells of their glutathione, while increasing, or at least maintaining, glutathione levels in healthy cells.

This is exactly what whey protein does. In this new research, it was discovered that cancer cells exposed to whey proteins were depleted of their glutathione, and their growth was inhibited, while normal cells had an increase in GSH and increased cellular growth.

These effects were not seen with other proteins. Not surprisingly, the researchers concluded, “Selective depletion of tumor GSH may in fact render cancer cells more vulnerable to the action of chemotherapy and eventually protect normal tissue against harmful effects of chemotherapy.” The exact mechanism by which whey protein achieves this is not fully understood, but it appears to interfere with the normal glutathione feedback and regulation mechanism in cancer cells.

It is known that glutathione production is negatively inhibited by its own synthesis. Because the baseline level of glutathione is higher in cancer cells than in normal cells, it is likely that it is easier to achieve a level of negative feedback inhibition in the glutathione levels of cancer cells than in the glutathione levels of normal cells.

Whey and LDL Cholesterol

The positive health benefits of whey protein concentrate do not end with its effects on immunity and cancer prevention and treatment. Whey protein concentrate has also been found to be a potent inhibitor of oxidized low density lipoprotein cholesterol. Current research suggests that the conversion of LDL to oxidized LDL is the trigger that leads to atherogenesis… the formation of plaque and lesions associated with atherosclerosis.

Therefore, any substance that inhibits the oxidation of LDL is thought to be anti-atherogenic. Although animal-based proteins have traditionally been implicated as pro-atherogenic, whey proteins appear to be an exception to the rule. Whey protein consists of several minor and major fractions, such as beta-lactoglobulin, alpha-lactalbumin, albumin, lactoferrin and immunoglobulin. It was discovered that the minor constituent responsible for the ability of whey protein concentrate to prevent oxidation of LDL appears to be the lactoferrin fraction of the protein. 3

Lactoferrin In Whey

When lactoferrin was removed from the protein, the ability of whey-protein concentrate to prevent LDL oxidation was greatly reduced, leading the researchers to speculate, “Our results suggest that LF (lactoferrin) is the main factor responsible for the inhibitory effect of whey protein (on LDL) and it can work synergistically with other factors in whey protein, for example, alpha-lactalbumin.”

Another study using rats examined the effects of whey protein concentrate and casein on cholesterol and the risk factors of heart disease. Although casein (another milk-based protein commonly used in research) is known to raise cholesterol in humans and animals, whey protein has the opposite effect, leading researchers to note, “In high that is the level of protein in the diet. [300 gram per kilogram of feed] whey protein significantly lowers plasma and liver cholesterol and also plasma triacylglycerols.” 4

The cholesterol-lowering effects of whey protein concentrate in this study were also associated with a reduction in LDL cholesterol. Most interesting is the fact that this effect on cholesterol was not seen when animals were fed amino acid mixtures that simulated whey protein, so it is clear that there are properties within whey that have these effects. which is more than just its amino acid profile.

Whey and Bone Growth

Finally, whey protein appears to play a direct role in bone growth. Researchers found that mice fed whey protein concentrate showed increased bone strength and bone protein like collagen. This discovery led to research to test whether whey protein directly stimulated osteoblast (bone cell) growth in vitro.

Whey protein was found to stimulate, dose-dependently, total protein synthesis, DNA content, and increased hydroxyproline content of bone cells. 5

It should be noted that not all whey protein concentrates are created equal. Processing whey protein to remove lactose and fat without losing its biological activity requires special care by the manufacturer. The protein must be processed under low temperature and low acid conditions so as not to “denature” the protein. Maintaining the protein’s natural state is essential to its biological activity.

These research findings, combined with the past decade of whey protein studies, should convince anyone that whey protein concentrate really is the life-extension protein.

Higher Levels of Glutathione and Whey

A decade and a half of discoveries into the benefits of whey protein is overwhelming.

Previous Studies include the following:

* Whey protein concentrate dramatically increases glutathione levels. Glutathione is an important water-soluble antioxidant in the body that protects cells and serves as the primary detoxifier of harmful compounds such as peroxides, heavy metals, carcinogens and other toxins.

* Glutathione is also closely tied to immunity, and reduced glutathione levels are associated with disease such as AIDS, atherosclerosis, Alzheimer’s disease and Parkinson’s disease, to name just a few. In fact, glutathione levels appear to be a way of modulating immunity. 6

* Whey protein concentrate has been found to consistently increase this vital immune stimulating antioxidant more than any other protein studied (including soy) to higher than normal levels in multiple animal studies . 7

A small pilot study with HIV-positive men fed whey protein concentrate found dramatic increases in the glutathione levels of all study participants, with two out of three men to reach their ideal body weight. 8

In fact, there are several US and international patents granted for the treatment of AIDS and improving immunity to whey protein concentrates.

* Whey protein improves immune function and fights infections. Animals fed whey protein concentrate have consistently shown dramatic enhancement of both humoral and cellular immune responses to various immune challenges, such as salmonella, streptococcus pneumonia 9 and severe cancer-causing chemicals. This effect on immunity was not seen with other proteins.

* Whey protein concentrate fights cancer. Animals are fed whey protein.

Sources

1. (McIntosh GH,. et al., Journal of Nutrition, 1995)

2. (Kennedy RS, Konok GP, Bounous G., Baruchel S., Lee TD, Cancer Research, 1995)

3. (M. Kajikawa et al. Biochemica et Biophysica Acta, 1994)

4. (Zhang X. and Beynen AC Brit. J. of Nutri., 1993)

5. (Takada Y., Aoe S., Kumegawa M., Biochemical Research Communications, 1996)

6. (Rosanne K., Fidelus and Min Fu Tsan. Cellular Immunology, 1986)

7. (Bounous G. and Gold P., Clin. Invest. Med. 1991)

8. (Bounous G., Baruchel S., Faiutz J., Gold P., Clin. Invest. Med. 1992)

9. (Bounous G., Konshavn P., Gold P., Clin. Invest. Med. 1988)

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